李博，女，1982年3月15日出生，博士研究生。从2013年至今一直从事听力语言与康复学。2001.09-2005-06就读于江南大学食品科学工程专业，2006.

09-2010.06在延边大学生物化学与分子生物学专业攻读硕士，同时2008.03-20

10.02在韩国全北国立大学药理学专业攻读硕士，2010.09-2013.08在在韩国全北国立大学药理学专业攻读博士。毕业后2013.09至今在我校特殊教育学院担任讲师，2013.11-2014.11及2015.09-2015.12在美国凯斯西储大学耳鼻喉系为博士后及访问学者。其担任主要课程为神经科学、特殊教育医学基础，听力与言语康复学研究方法。主要研究领域为儿科疾病致病机理研究及治疗药物开发。

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承担科研项目情况：

国家自然科学基金青年基金，内质网应激参与钙粘素突变小鼠的听力损伤机制研究，2015.01-2017.12，20万元，主持

国家自然科学基金重点项目，遗传性耳聋致病机理和药物新靶点的研究，2016.01-2020.12，273万元，参与

国家自然科学基金青年基金，*******衍生物对钙黏蛋白突变小鼠CDH23erl/erl的听力保护作用及机制研究，2016.01-2018.12，18万元，参与

国家自然科学基金青年基金，基于新型高效SERS传感器同步检测体液中多种致病菌耐药性的研究，2017.01-2019.12，17万元，参与发表论文

  Cui Y, Bhandary B, Marahatta A, Lee GH, Li B, Kim DS, Chae SW, Kim HR, Chae HJ. Characterization of Salvia miltiorrhiza ethanol extract as an anti-osteoporotic agent. BMC complementary and alternative medicine. 2011, 11:120.

2.       Li B, Reed JC, Kim HR, Chae HJ. Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice. Molecules and cells. 2012, 34(1):15-23.

3.       Kim DS^#, Li B^#, Rhew KY, Oh HW, Lim HD, Lee W, Chae HJ, Kim HR. The regulatory mechani** of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts. Archives of pharmacal research. 2012, 35(7):1269-1278.

4.       Li B, Kim DS, Oh HW, Lim HD, Lee W, Rhew KY, Kim HR, Chae HJ. N-Nitrosodimethylamine induced lung fibroblast cell death is associated with JNK activation. Molecular & Cellular Toxicology. 2012, 8(2):155-161.

5.       Lee HY, Kim JH, Jeung HW, Lee CU, Kim DS, Li B, Lee GH, Sung MS, Ha KC, Back HI, Kim SY, Park SH, Oh MR, Kim MG, Jeon JY, Im YJ, Hwang MH, So BO, Shin SJ, Yoo WH, Kim HR, Chae HJ, Chae SW. Effects of Ficus carica paste on loperamide-induced constipation in rats. Food and chemical toxicology. 2012, 50(3-4):895-902.

6.       Jin CF^#, Li B^#, Lin SM, Yadav RK, Kim HR, Chae HJ. Mechani** of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl4 -Induced Acute Liver Lipid Accumulation in Rats. International journal of endocrinology. 2013, 2013:751854.

7.       Li B, Yadav RK, Kim HR, Chae HJ. The characteristics of Bax inhibitor-1 and its related diseases. Current molecular medcine. 2014, 14(5):603-15.

8.       Lee GH, Lee HY, Li B, Kim HR, Chae HJ. Bax inhibitor-1-mediated inhibition of mitochondrial Ca2+ intake regulates mitochondrial permeability transition pore opening and cell death. Scientific reports. Sci Rep. 2014, (5)4:5194.

9.       Li B, Kim D S, Yadav R K, Kim H R, Chae H J. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015;36(1):53-64.

10.   Yadav R K, Lee G H, Lee H Y, Li B, Jung H E, Rashid H O, Choi M K, Yadav B K, Kim W H, Kim K W, Park B H, Kim W, Lee Y C, Kim H R, Chae H J. TMBIM6 (tran**embrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model. Autophagy. 2015;11(10):1760-74.

11.   Hu J, Li B, Apisa L, Yu H, Entenman S, Xu M, Stepanyan R, Guan B, Müller U, Hatzoglou M, Zheng Q Y. ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice. Cell Death Dis. 2016;7(11):e2485.

12.   Hu J, Xu M, Yuan J, Li B, Entenman S, Yu H, Zheng Q Y. Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. Neuroscience. 2016;316:311-20.

13.   Wang Q, Zhao H, Zheng T, Wang W, Zhang X, Wang A, Li B, Wang Y, Zheng Q. Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss. J Neurosci Res. 2017;95(10):1937-1950.

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